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1

Kinetic and modelling studies on the lipase catalysed enantioselective esterification of (±)-perillyl alcohol

Vasso Skouridou, Evangelia D Chrysina, Haralambos Stamatis, Nikos G Oikonomakos, Fragiskos N Kolisis

Journal:

Journal of Molecular Catalysis B: Enzymatic

Année:

2004

Langue:

english

Fichier:

PDF, 113 KB

english, 2004

2

New Synthetic Seven-Membered 1-Azasugars Displaying Potent Inhibition Towards Glycosidases and Glucosylceramide Transferase

Hongqing Li, Tao Liu, Yongmin Zhang, Sylvain Favre, Claudia Bello, Pierre Vogel, Terry D. Butters, Nikos G. Oikonomakos, Jérôme Marrot, Yves Blériot

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 318 KB

english, 2008

3

In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones – Inhibition of and Binding to Glycogen Phosphorylase in the Crystal

Li He, Yun Zhi Zhang, Marcelle Tanoh, Guo-Rong Chen, Jean-Pierre Praly, Evangelia D. Chrysina, Costas Tiraidis, Magda Kosmopoulou, Demetres D. Leonidas, Nikos G. Oikonomakos

Journal:

European Journal of Organic Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 279 KB

english, 2007

4

Cooperative Interactions of the Catalytic Nucleophile and the Catalytic Acid in the Inhibition of β-Glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b

Tom D. Heightman, Andrea Vasella, Katerina E. Tsitsanou, Spyros E. Zographos, Vicky T. Skamnaki, Nikos G. Oikonomakos

Journal:

Helvetica Chimica Acta

Année:

1998

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1998

5

α-Azidoesters as divergent intermediates for combinatorial generation of glucofuranose libraries of novel N-linked glycopeptides

Tilmann W. Brandstetter, Carmen de la Fuente, Yong-ha Kim, Richard I. Cooper, David J. Watkin, Nikos G. Oikonomakos, Louise N. Johnson, George W.J. Fleet

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 606 KB

english, 1996

6

Spirohydantoins of glucofuranose: Analogues of hydantocidin

Tilmann W. Brandstetter, Yong-ha Kim, Jong Chan Son, Helen M. Taylor, Paul M. de Q. Lilley, David J. Watkin, Louise N. Johnson, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 257 KB

english, 1995

7

Potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose: First pyranose analogues of hydantocidin

Claire J.F. Bichard, Edward P. Mitchell, Mark R. Wormald, Kimberley A. Watson, Louise N. Johnson, Spyros E. Zographos, Demetra D. Koutra, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 287 KB

english, 1995

8

7-Carbon mimics of D-glucose and L-fucose: Activation by 6R-, and inactivation by 6S, -6C-methylglucose of glycogen synthase: Inhibition of glucokinase and/or glucose-6-phosphatase

Yves Blériot, Kathryn H. Smelt, Joan Cadefau, Mathieu Bollen, Willy Stalmans, Keith Biggadike, Louise N. Johnson, Nikos G. Oikonomakos, Alexandra L. Lane, Sarah Crook, David J. Watkin, George W.J. Fle

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 279 KB

english, 1996

9

Binding of β-d-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies

Evangelia D. Chrysina, Magda N. Kosmopoulou, Rozina Kardakaris, Nicolas Bischler, Demetres D. Leonidas, Thanukrishnan Kannan, Duraikkannu Loganathan, Nikos G. Oikonomakos

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 566 KB

english, 2005

10

Binding of oxalyl derivatives of β-d-glucopyranosylamine to muscle glycogen phosphorylase b

Theodoros Hadjiloi, Costas Tiraidis, Evangelia D. Chrysina, Demetres D. Leonidas, Nikos G. Oikonomakos, Panagiotis Tsipos, Thanasis Gimisis

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2006

11

Crystallographic studies on N-azidoacetyl-β-d-glucopyranosylamine, an inhibitor of glycogen phosphorylase: Comparison with N-acetyl-β-d-glucopyranosylamine

Evangelia I. Petsalakis, Evangelia D. Chrysina, Costas Tiraidis, Theodoros Hadjiloi, Demetres D. Leonidas, Nikos G. Oikonomakos, Udayanath Aich, Babu Varghese, Duraikkannu Loganathan

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 637 KB

english, 2006

12

A galactopyranose analogue of hydantocidin

Tilmann W. Brandstetter, Mark R. Wormald, Raymond A. Dwek, Terry D. Butters, Frances M. Platt, Katerina E. Tsitsanou, Spyros E. Zographos, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Année:

1996

Langue:

english

Fichier:

PDF, 742 KB

english, 1996

13

The binding of 3′-N-piperidine-4-carboxyl-3′-deoxy-ara-uridine to ribonuclease A in the crystal

Demetres D. Leonidas, Tushar Kanti Maiti, Anirban Samanta, Swagata Dasgupta, Tanmaya Pathak, Spyros E. Zographos, Nikos G. Oikonomakos

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2006

14

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site

Laura J. Hampson, Catherine Arden, Loranne Agius, Minas Ganotidis, Magda N. Kosmopoulou, Costas Tiraidis, Yiannis Elemes, Constantinos Sakarellos, Demetres D. Leonidas, Nikos G. Oikonomakos

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 273 KB

english, 2006

15

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors

Kyra-Melinda Alexacou, Alia-Cristina Tenchiu (Deleanu), Evangelia D. Chrysina, Maria-Despoina Charavgi, Ioannis D. Kostas, Spyros E. Zographos, Nikos G. Oikonomakos, Demetres D. Leonidas

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.04 MB

english, 2010

16

Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies

Paul R.O. Whittamore, Matthew S. Addie, Stuart N.L. Bennett, Alan M. Birch, Michael Butters, Linda Godfrey, Peter W. Kenny, Andrew D. Morley, Paul M. Murray, Nikos G. Oikonomakos, Ludovic R. Otterbein

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 194 KB

english, 2006

17

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors

Alan M. Birch, Peter W. Kenny, Nikos G. Oikonomakos, Ludovic Otterbein, Paul Schofield, Paul R.O. Whittamore, Dave P. Whalley

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 382 KB

english, 2007

18

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a d-glucotriazole carboxylate

Thomas M. Krülle, Carmen de la Fuente, Lea Pickering, Robin T. Aplin, Katerina E. Tsitsanou, Spyros E. Zographos, Nikos G. Oikonomakos, Robert J. Nash, Rhodri C. Griffiths, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Année:

1997

Langue:

english

Fichier:

PDF, 1005 KB

english, 1997

19

Kinetic and Crystallographic Studies of Glucopyranosylidene Spirothiohydantoin Binding to Glycogen Phosphorylase b

Nikos G Oikonomakos, Vicky T Skamnaki, Erzsébet Ösz, László Szilágyi, László Somsák, Tibor Docsa, Béla Tóth, Pál Gergely

Journal:

Bioorganic & Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 403 KB

english, 2002

20

The 1.76 Å Resolution Crystal Structure of Glycogen Phosphorylase b Complexed with Glucose, and CP320626, a Potential Antidiabetic Drug

Nikos G Oikonomakos, Spyros E Zographos, Vicky T Skamnaki, Georgios Archontis

Journal:

Bioorganic & Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 372 KB

english, 2002

21

Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 Å resolution

Nikos G. Oikonomakos, Evangelia D. Chrysina, Magda N. Kosmopoulou, Demetres D. Leonidas

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2003

Langue:

english

Fichier:

PDF, 846 KB

english, 2003

22

The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor

Maria Kontou, Demetres D Leonidas, Efstratia H. Vatzaki, Panayiota Tsantili, Avgi Mamalaki, Nikos G. Oikonomakos, K. Ravi Acharya, Socrates J. Tzartos

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 673 KB

english, 2000

23

Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies

Konstantinos Poulas, Elias Eliopoulos, Efstratia Vatzaki, Jorge Navaza, Maria Kontou, Nikos Oikonomakos, K. Ravi Acharya, Socrates J. Tzartos

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 757 KB

english, 2001

24

Binding of N-acetyl-N ′-β-d-glucopyranosyl urea and N-benzoyl-N ′-β-d-glucopyranosyl urea to glycogen phosphorylase b : Kinetic and crystallographic studies

Nikos G. Oikonomakos, Magda Kosmopoulou, Spyros E. Zographos, Demetres D. Leonidas, Evangelia D. Chrysina, László Somsák, Veronika Nagy, Jean-Pierre Praly, Tibor Docsa, Béla Tóth, Pál Gergely

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 603 KB

english, 2002

25

Crystallization and preliminary crystallographic study of an Fab fragment of a pathogenic rat monoclonal antibody against the nicotinic acetylcholine receptor

Efstratia H. Vatzaki, Socrates J. Tzartos, K. Ravi Acharya, Nikos G. Oikonomakos

Journal:

Protein Science

Année:

1993

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1993

26

Activator anion binding site in pyridoxal phosphorylase b: The binding of phosphite, phosphate, and fluorophosphate in the crystal

Nikos G. Oikonomakos, Spyros E. Zographos, Katerina E. Tsitsanou, Louise N. Johnson, K. Ravi Acharya

Journal:

Protein Science

Année:

1996

Langue:

english

Fichier:

PDF, 6.46 MB

english, 1996

27

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding

Mary Gregoriou, Martin E. M. Noble, Kimberly A. Watson, Elspeth F. Garman, Louise N. Johnson, Thomas M. Krulle, Carmen De La Fuetene, George W.J. Fleet, Nikos G. Oikonomakos

Journal:

Protein Science

Année:

1998

Langue:

english

Fichier:

PDF, 7.12 MB

english, 1998

28

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Kimberly A. Watson, Evangelia D. Chrysina, Katerina E. Tsitsanou, Spyros E. Zographos, Georgios Archontis, George W.J. Fleet, Nikos G. Oikonomakos

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2005

Langue:

english

Fichier:

PDF, 681 KB

english, 2005

29

The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-state and R-state features

Christine M. Lukacs, Nikos G. Oikonomakos, Robert L. Crowther, Li-Na Hong, R. Ursula Kammlott, Wayne Levin, Shirley Li, Chao-Min Liu, Debra Lucas-McGady, Sherrie Pietranico, Linda Reik

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2006

Langue:

english

Fichier:

PDF, 191 KB

english, 2006

30

Crystallographic and computational studies on 4-phenyl-N-(β-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with α-D-glucose, N-acetyl-β-D-glucopyranosylamine and N-benzoyl-N′-β-D-glucopyranosyl urea binding

Kyra-Melinda Alexacou, Joseph M. Hayes, Costas Tiraidis, Spyros E. Zographos, Demetres D. Leonidas, Evangelia D. Chrysina, Georgios Archontis, Nikos G. Oikonomakos, Jashuva V. Paul, Babu Varghese, Dur

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2008

Langue:

english

Fichier:

PDF, 662 KB

english, 2008

31

Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: The role of water molecules examined

Joseph M. Hayes, Vicky T. Skamnaki, Georgios Archontis, Christos Lamprakis, Josephine Sarrou, Nicolas Bischler, Alexios-Leandros Skaltsounis, Spyros E. Zographos, Nikos G. Oikonomakos

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2011

Langue:

english

Fichier:

PDF, 665 KB

english, 2011

32

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

Christina E. Drakou, Anna Malekkou, Joseph M. Hayes, Carsten W. Lederer, Demetres D. Leonidas, Nikos G. Oikonomakos, Angus I. Lamond, Niovi Santama, Spyros E. Zographos

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2012

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2012

33

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

Evangelia D. Chrysina, Éva Bokor, Kyra-Melinda Alexacou, Maria-Despoina Charavgi, George N. Oikonomakos, Spyros E. Zographos, Demetres D. Leonidas, Nikos G. Oikonomakos, László Somsák

Journal:

Tetrahedron: Asymmetry

Année:

2009

Langue:

english

Fichier:

PDF, 1.75 MB

english, 2009

34

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b : Comparison with ligand binding to pCDK2–cyclin A complex

Magda N. Kosmopoulou, Demetres D. Leonidas, Evangelia D. Chrysina, Nicolas Bischler, Gerhard Eisenbrand, Constantinos E. Sakarellos, Richard Pauptit, Nikos G. Oikonomakos

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 669 KB

english, 2004

35

The binding of IMP to Ribonuclease A

George N. Hatzopoulos, Demetres D. Leonidas, Rozina Kardakaris, Joze Kobe, Nikos G Oikonomakos

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 503 KB

english, 2005

36

High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors

Demetres D. Leonidas, Gayatri B. Chavali, Nikos G. Oikonomakos, Evangelia D. Chrysina, Magda N. Kosmopoulou, Metaxia Vlassi, Claire Frankling, K. Ravi Acharya

Journal:

Protein Science

Année:

2003

Langue:

english

Fichier:

PDF, 638 KB

english, 2003

37

Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs

Nikos G. Oikonomakos, Magda N. Kosmopoulou, Evangelia D. Chrysina, Demetres D. Leonidas, Ioannis D. Kostas, K. Ulrich Wendt, Thomas Klabunde, Elisabeth Defossa

Journal:

Protein Science

Année:

2005

Langue:

english

Fichier:

PDF, 767 KB

english, 2005

38

FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase

Costas Tiraidis, Kyra-Melinda Alexacou, Spyros E. Zographos, Demetres D. Leonidas, Thanasis Gimisis, Nikos G. Oikonomakos

Journal:

Protein Science

Année:

2007

Langue:

english

Fichier:

PDF, 1018 KB

english, 2007

39

Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate

Nikos G. Oikonomakos, Katerina E. Tsitsanou, Spyros E. Zographos, Vicky T. Skamnaki, Siegfried Goldmann, Hilmar Bischoff

Journal:

Protein Science

Année:

1999

Langue:

english

Fichier:

PDF, 8.38 MB

english, 1999

40

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure

Katerina E. Tsitsanou, Nikos G. Oikonomakos, Spyros E. Zographos, Vicky T. Skamnaki, Mary Gregoriou, Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet

Journal:

Protein Science

Année:

1999

Langue:

english

Fichier:

PDF, 1.64 MB

english, 1999

41

Sulphate activates phosphorylase b by binding to the Ser (P) site

Demetrios D. Leonidas, Nikos G. Oikonomakos, Anastassios C. Papageorgiou

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1991

Langue:

english

Fichier:

PDF, 270 KB

english, 1991

42

Halogen-substituted (C-β-d-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase

Kyra-Melinda Alexacou, Yun Zhi Zhang, Jean-Pierre Praly, Spyros E. Zographos, Evangelia D. Chrysina, Nikos G. Oikonomakos, Demetres D. Leonidas

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2011

43

The Structure of Phosphorylase Kinase Holoenzyme at 9.9 Å Resolution and Location of the Catalytic Subunit and the Substrate Glycogen Phosphorylase

Catherine Vénien-Bryan, Slavica Jonic, Vasiliki Skamnaki, Nick Brown, Nicolas Bischler, Nikos G. Oikonomakos, Nicolas Boisset, Louise N. Johnson

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2009

44

A new allosteric site in glycogen phosphorylase b as a target for drug interactions

Nikos G Oikonomakos, Vicky T Skamnaki, Katerina E Tsitsanou, Nikos G Gavalas, Louise N Johnson

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 625 KB

english, 2000

45

The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor

Spyros E Zographos, Nikos G Oikonomakos, Katerina E Tsitsanou, Demetrios D Leonidas, Evangelia D Chrysina, Vicky T Skamnaki, Hilmar Bischoff, Siegfried Goldmann, Kimberly A Watson, Louise N Johnson

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 812 KB

english, 1997

46

Uridine(5′)diphospho(1)-α-d-glucose : A binding study to glycogen phosphorylase b in the crystal

Nikos G. OIKONOMAKOS, K. Ravindra ACHARYA, David I. STUART, Angeliki E. MELPIDOU, Paul J. McLAUGHLIN, Louise N. JOHNSON

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1988

47

Structural Basis of the Synergistic Inhibition of Glycogen Phosphorylase a by Caffeine and a Potential Antidiabetic Drug

Katerina E. Tsitsanou, Vicky T. Skamnaki, Nikos G. Oikonomakos

Journal:

Archives of Biochemistry and Biophysics

Année:

2000

Langue:

english

Fichier:

PDF, 345 KB

english, 2000

48

Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor

Maria Kontou, Efstratia H. Vatzaki, Anna Kokla, K.Ravi Acharya, Nikos G. Oikonomakos, Socrates J. Tzartos

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 488 KB

english, 1996

49

Structural Basis for the Carbohydrate Recognition of the Sclerotium rolfsii Lectin

Demetres D. Leonidas, Bale M. Swamy, George N. Hatzopoulos, Sathisha J. Gonchigar, Vishwanath B. Chachadi, Shashikala R. Inamdar, Spyros E. Zographos, Nikos G. Oikonomakos

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2007

50

The binding of β- and γ-cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies

Nikos Pinotsis, Demetres D. Leonidas, Evangelia D. Chrysina, Nikos G. Oikonomakos, Irene M. Mavridis

Journal:

Protein Science

Année:

2003

Langue:

english

Fichier:

PDF, 420 KB

english, 2003